Anthony Ciccone, Madonna’s oldest brother, has died from respiratory failure and oropharyngeal cancer caused by smoking. The death certificate indicates that tobacco use contributed to his death. Ciccone had been receiving treatment at a Michigan nursing facility, with Madonna paying for his care. Despite a challenging relationship, sources suggest that the family had always had his best interests at heart. Oropharyngeal cancer is a serious illness that affects the back of the throat and is often linked to smoking. Learn more here.