NCDC Confirms 13 New Cases Of Lassa Fever

The Nigeria Centre for Disease Control (NCDC), has confirmed 13 additional new cases of Lassa fever in seven days from five states, which were; Ondo, Edo, Kogi, Ebonyi, and Imo.

The NCDC in its epidemiological report made available on Monday said that, since the beginning of 2022, 70 percent of infections had come from three states: Ondo (31 percent), Edo (26 percent), and Bauchi (13 percent).

Lassa fever is an acute viral hemorrhagic illness caused by the Lassa virus. People usually become infected with the Lassa virus through exposure to food or household items contaminated with urine or feces of infected rats – present in several West African countries where the disease is endemic.

The virus could also be spread through infected bodily fluids. The public health agency said that the country had recorded 165 deaths in 17 states.

The agency said,” In week 31 (Aug. 1 to 7), the number of new confirmed cases increased from 10 in week 30, 2022 to 13 cases. These were reported from Ondo, Edo, Kogi, Ebonyi, and Imo states.

“Cumulatively from week 1 to week 31, 2022, 165 deaths have been reported with a case fatality rate (CFR) of 18.8 percent which is lower than the CFR for the same period in 2021 (23.1 percent).

“In total for 2022, 25 States have recorded at least one confirmed case across 100 Local Government Areas.

“Of all confirmed cases, 70 percent are from Ondo (31 percent), Edo (26 percent), and Bauchi (13 percent) States,”

The NCDC stated that the predominant age group affected was 21-30 years (Range. zero to 90 years, Median Age: 30 years.

It said that the male-to-female ratio for confirmed cases was 1:0.8. “The number of suspected cases has increased compared to that reported for the same period in 2021.

“No new Healthcare worker affected in the reporting week 31,” it said.

The NCDC, however, said that the National Lassa fever multi-partner, multi-sectoral Technical Working Group (TWG) had continued to coordinate the response activities at all levels.

It could be recalled that the number of suspected cases had increased compared to that reported for the same period in 2021.

Meanwhile, the agency did not state if there were any new Healthcare workers affected in reporting week 31.

Lassa fever was first discovered in Nigeria when two missionary nurses became ill with the virus in 1969. Its name is derived from the village of Lassa, where it was first documented.

Lassa fever is a viral infection carried by the multimammate rat Mastomys natalensis (M. natalensis).

This is one of the most common rodents in equatorial Africa, found across much of sub-Saharan Africa.

Lassa fever mainly occurs in Sierra Leone, Liberia, Guinea, and Nigeria. However, the Mastomys rat is common in neighboring countries, so these areas are also at risk.

Once a Mastomys rat is infected with the virus, it can excrete trusted sources of the virus in its feces and urine, potentially for the rest of its life.
As a result, the virus can spread easily, especially as the rats breed rapidly and can inhabit human homes.

The most common method of transmission is by consuming or inhaling rat urine or feces. It can also be spread through cuts and open sores.

The rats live in and around human habitation, and they often come into contact with foodstuffs. Sometimes people eat the rats, and the disease can be spread during their preparation.

Person-to-person contact is possible via blood, tissue, secretions, or excretions, but not through touch. Sharing needles may spread the virus, and there are some reports of sexual transmission.

Lassa fever can also be passed between patients and staff at poorly equipped hospitals where sterilization and protective clothing are not standard.

Meanwhile, a new vaccine shows promise to fight the Lassa virus.

Researchers at the University of Texas Medical Branch have achieved success with a new vaccine developed to fight Lassa Virus, a pathogen that causes Lassa fever.

Lassa fever is lethal in humans and nonhuman primates with a mortality rate as high as 70 percent in hospitalized cases.

As many as 500,000 people are infected each year in West Africa. Lassa fever may also induce serious long-lasting effects in survivors.

As many as one-third of those infected suffer hearing loss or other neurological complications.

The study, “A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever,” was published July 19 in Cell Reports.